ea0059p104 | Diabetes & cardiovascular | SFEBES2018
Pizza Grazia
, Nguyen-Tu Marie-Sophie
, Cebola Ines
, Yavari Arash
, Marchetti Piero
, Piemonti Lorenzo
, De Koning Eelco
, Shapiro AM James
, Johnson Paul
, Sakamoto Kei
, Smith David M
, Leclerc Isabelle
, Ashrafian Houman
, Ferrer Jorge
, Martinez-Sanchez Aida
Introduction: Pancreatic β-cells control glucose homeostasis by secreting insulin in response to high glucose. MiRNAs regulate β-cell function and contribute to β-cell failure in type 2 diabetes. MiR-184 regulates β-cell compensatory expansion during pregnancy and obesity and its expression is reduced by glucose through unknown mechanisms. AMPK is a suggested target of antidiabetic drugs and an important energy sensor. Its β-cell-selective inactivation...